Search results for "articular cartilage lesion"

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Evaluation of a Cell-Free Collagen Type I-Based Scaffold for Articular Cartilage Regeneration in an Orthotopic Rat Model.

2020

The management of chondral defects represents a big challenge because of the limited self-healing capacity of cartilage. Many approaches in this field obtained partial satisfactory results. Cartilage tissue engineering, combining innovative scaffolds and stem cells from different sources, emerges as a promising strategy for cartilage regeneration. The aim of this study was to evaluate the capability of a cell-free collagen I-based scaffold to promote cartilaginous repair after orthotopic implantation in vivo. Articular cartilage lesions (ACL) were created at the femoropatellar groove in rat knees and cell free collagen I-based scaffolds (S) were then implanted into right knee defect for the…

Settore BIO/17 - IstologiaPathologymedicine.medical_specialtyScaffoldcartilage tissue engineeringcollagen I-based scaffold02 engineering and technologySOX9lcsh:TechnologyArticle03 medical and health sciencesIn vivoarticular cartilage lesionmedicineGeneral Materials Sciencelcsh:Microscopycartilage regenerationAggrecan03 Chemical Sciences 09 Engineering030304 developmental biologylcsh:QC120-168.850303 health scienceslcsh:QH201-278.5Chemistrylcsh:TCartilageRegeneration (biology)021001 nanoscience & nanotechnologymusculoskeletal systemmedicine.anatomical_structurelcsh:TA1-2040ImmunohistochemistryArticular cartilage lesion; Cartilage regeneration; Cartilage tissue engineering; Collagen i-based scaffold; Orthotopic implantationlcsh:Descriptive and experimental mechanicslcsh:Electrical engineering. Electronics. Nuclear engineeringStem cellorthotopic implantation0210 nano-technologylcsh:Engineering (General). Civil engineering (General)lcsh:TK1-9971
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